ABSTRACT
Introduction: The present study examines clinical features of patients infected with the 2019 sever acute respiratory syndrome coronavirus 2(SARS-Cov-2) leading to the coronavirus disease 2019 (covid-2019) in Rasool Akram hospital, Tehran, Iran. Material(s) and Method(s): This was a retrospective case report performed at Rasool Akram hospital, Tehran, Iran. A total of 77 patients referred to the hospital with SARS-Covid-2 infection. Data of the present study has been collected from March 5th to April 5th 2020. Result(s): Intensive care unit (ICU) has admitted 20 patients out of 77 patients. Among this sample, 23 patients were infected with acute respiratory syndrome and the other 18 remaining passed away. The calculated mean age of the patients admitted to the ICU was 60.8, 18 out of whom had deceased. In our results, male patients outnumber female patients where male patients account for 62.33% and female patients account for 37.66% of the whole study population. The most frequent and usual sings of this disease first reported as respirational distress or dyspnea (54.54%), coughs (54.54%) and myalgia (25.97). Only 3.89% of the patients had chest pain or chest discomfort. The most common comorbidities among those patients taken in the ICU and or deceased were diabetes, cardiovascular problems, hypertension and endocrine system problems. Out of 18 deaths, 11 (61.11%) cased had comorbidities. Among radiography and CT-scan results, 62.79% of the patients had involvement on chest radiography and 98.15% of the patients showed consolidation with ground glass opacities and 83.33% showed pleural effusion on their scan results. Conclusion(s): Having as much thorough information as possible about the characteristics of the patients infected with this virus helps us make better and sooner judgmental calls and more accurate diagnosis.Copyright © 2020 Ubiquity Press. All rights reserved.
ABSTRACT
Introduction: This study aims to measure the diagnostic accuracy of chest computed tomography (CT) and reverse transcription polymerase chain reaction assay (RT-PCR) in COVID-19 in a systematic review and metaanalysis. Methods: PubMed, Scopus, Embase, and Google Scholar, WHO, SSRN, and MedRxiv have been searched on March 26, 2020 for all the alternative names of the disease and virus. Risk of bias assessment was based on QUADAS-2. Data from English-language studies after January 12, 2019 were pooled to calculate necessary diagnostic values and underwent diagnostic test accuracy, random-effects, proportions, and subgroup metaanalysis. Results: Pooled from 27 included studies, the sensitivity of chest CT was calculated 96.6%, specificity 22.5%, diagnostic odds ratio (DOR) 8.2, positive likelihood ratio (PLR) 1.2 (95% CI: 1.1-1.4), and negative likelihood ratio (NLR) 0.15 (95% CI: 0.1-0.3). The sensitivity for initial RT-PCR was 79.7%, the specificity 100%, and NLR 0.18. Conclusion: Considering the results, in order to diagnose COVID-19 (coronavirus disease 2019), it is recommended to initially performing chest CT to rule out the uninfected people. In suspicious cases, we suggest RT-PCR to confirm the disease. Performing serial RT-PCR instead of the one-time test is highly recommended, to let the viral loads reach the diagnostic levels, especially in cases of high clinical suspicion.